虽然他的早期作品与光线和阴影的对比而言，他的最终转会到威尼斯在1620年初修改了他的风格和推动了绚丽的色彩和一个充满活力的治疗绘surface.In 1627年，他创建了一个大的钦佩祭坛的圣杰罗姆的启示在圣尼科洛达托伦蒂诺。他的笔触松动似乎先导，以洛可可风格的瓜 brothers.This最终的风格，与居住在威尼斯，其他的“外来”的画家一起多梅尼科Fetti和贝尔纳多·斯特罗齐，代表了巴洛克风格的第一次大举进入共和国。
Liss was born in Oldenburg (Holstein) in Schleswig-Holstein, Germany. After an initial education in his home state, he continued his studies, according to Houbraken, with Hendrick Goltzius in Haarlem andAmsterdam. Around 1620 he travelled through Paris to Venice. He moved to Rome around 1620–1622, and his first works there were influenced by the style of Caravaggio.
Although his earlier work was concerned with the contrasts of light and shadow, his final move to Venicein the early 1620s modified his style and gave impetus to brilliant color and a spirited treatment of the painted surface.In 1627, he was created an admired large altarpiece, the Inspiration of Saint Jerome inSan Nicolò da Tolentino. His loose brushstrokes seem precursor to rococo styles of Guardi brothers.This final style, along with that of other "foreign" painters residing in Venice, Domenico Fetti and Bernardo Strozzi, represent the first inroads of Baroque style into the republic.
Liss fled to Verona to escape the plague spreading in Venice, but succumbed there prematurely in 1629. According to Houbraken, he worked day and night on his paintings, so that Joachim von Sandrart felt that his health was at risk and urged him to join him in Rome
His legacy is as a painter of both sensuous mythological and pious biblical subjects, a master of colors and Baroque painting. He was most influential to Venetian 18th-century painters like Sebastiano Ricci,Giovanni Battista Tiepolo and Giovanni Piazzetta.
Joachim von Sandrart wrote in 1675 that "because he fared well in Venice, he soon returned there ... he died along with many others during the plague that began in 1629."