大多数Leyster的日期作品都是从1629年至1635年，这与前一段她结婚生子一致。有一些已知件1635后涂：在一本关于郁金香从1643年，从1652画像，并从1654这是最近在私人收藏发现了一个静物两幅插图 Leyster可能与她的丈夫协同工作为好。1660年死于Leyster 50岁。
Leyster was born in Harlem in January Willemsz Leyster, the local beer and clothmaker in eighth children. Although the details of her training is uncertain, she is not good enough, in 1628 known by the Holland book mentioned Samuel Ampzing entitled Beschrijvinge LOF Haerlem Hotel Ende des ashtart.
There is some speculation that Leyster pursued a career in painting as a result of her father's bankruptcy, the need to introduce funds to the family. She may have learned from painting Frans de Grebber Pietersz , who is running in 1620 to respect the workshop in Haarlem. During this period, her family moved to Utrecht, she may have been in contact with the Utrecht Caravaggio doctrine.
Her first known signing work entered the guild of artists 1629 years ago. By 1633, she was a member of the Haarlem guild of St. Luke, second female painter in registered there. The first woman Salafan registered Baalbergen in 1631, who love Leyster, is a member of the family is not an established artist in Haarlem, and she also married another painter; Barent van Eysen. There was a painter in Harlem, active women, but because they worked on family workshops, they do not need professional qualifications must be able to sign works or run) seminar.
Her self portrait, C. 1633 (National Gallery of art, Washington, D. C.), has been proposed as an introduction to her film association. The history of this self portrait marks the rigidity of the self portrait of the early female, instead of a more relaxed, dynamic gesture. In fact, it is by any standard portrait of Holland is very relaxed, more than the main and some haers. However, it seems unlikely that in reality, when she painted oil, especially in a wide lace collar to wear such a dress.
Within two years she entered the guild, Leyster took three male apprentices. Records show, Leyster sued Frans Hals accepted who left her workshop for haers one of her students, students after less than three days in the studio. The student's mother to pay punitive damages Leyster 4 Holland shield, just what Leyster, but instead of returning her apprentice half, haers payment to settle the argument three fine Holland shield. Leyster fined himself for unregistered Association apprentices.
In 1636, Leyster married Yang Miense MOLENAER, a similar theme of more produced artists. In the hope of a better economic outlook, they moved to Amsterdam, where his existing customers. They returned to Haarlem (where they stayed for eleven years before Himes Ted). In hymes Ted them together in a small house in the grounds of studio Groenendaal park. Leyster and MOLENAER had five children, and only about two lived to adulthood.
Most of Leyster's dates are from 1629 to 1635, which is consistent with her previous marriage and birth. There are some known 1635 after coating: in a book about tulips from 1643, from 1652 and 1654 from the portrait, which was recently discovered in a private collection of two illustrations may still Leyster with her husband to work together for good. 1660 died of Leyster 50 years old.